Still Hungry?

This sun has nothing to do with leptin,
I just like the pic!

Do you know anyone that can eat a whole pizza, chase with beer, and still be hungry for ice cream? If that person is overweight it may be because their leptin receptors are down. The more fat we have on our bodies the more leptin we are supposed to secrete. Leptin is the hormone that signals our hypothalamus that we are full and to stop eating and start burning fuel. This would make you think the more fat, the more leptin, the better! But, what really happens is similiar to diabetes. Just like insulin receptors, the leptin recepters function less efficiently when there is too much leptin. The process is very similiar to how insulin receptors do not let insulin communicate with our cells to use the sugar in our food for fuel, instead the receptors are bombarded and so they shut down. As a result an overweight person's body(hypothalamus regulates hunger and metablolism) is not telling him/her to stop eating. Like Type 2 diabetes losing weight, eating right, and exercising can reduce fat cells, therefore reduce the amount of leptin produced to a normal amount, therfore reversing leptin resistance.

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